Wild Oregano Oil and Black Seed Oil Neutralize Inflammatory Cytokines in Lungs and Other Tissues
Cass Ingram, D.O.
What an impressive finding it is and highly newsworthy. It is mentioned throughout the news the issue of “cytokine storm” and the danger this poses to people. Yet, incredibly, a mere wild plant and its essential oil are medicinal beyond all drugs, in fact, a litany of them. Wild oregano is a powerhouse for supporting the body’s inflammation response in the tissues. In a number of studies it has been found to inhibit the source of this condition primarily through its actions on inflammatory markers. Actually, the mechanism is truly profound, because wild oregano acts on the genes that lead to the synthesis of these markers. Repeatedly, it has been shown, oregano oil and its active components, including carvacrol and thymol, have demonstrated great powers against inflammation. In fact, in some studies oregano oil active ingredients were able to drop COX-2 inflammation levels by up to 80%.
Today, there is much concern about the inflammation that results from overwork of the immune system or might it be said, overreactions. In a study on T lymphocytes done via cell culture it was found that the wild oregano oil active ingredients exhibited a specific molecular action even more potent than drugs. Carvacrol and thymol both significantly reduced tissue levels of interleukin-2. In fact, the reduction was massive, two-thirds in the case of carvacrol. This makes it more significant in this regard than any drug. For gamma interferon the reduction was nearly 30%. This proved that the oregano oil component modified the activity, that is more towards normal, during a crisis event. Correlating this to humans aggressive dosing would likely reduce this further.
In the lungs oregano oil has been found to curb reactive oxygen species or free radicals. In asthma patients this has led to a reduction in cytokine overload. Here, it largely shuts off the gene responsible for the immunological storm reaction. Whether in the lungs or the skin—or the rest of the organs—cytokines are no match for the powers of wild oregano.
In another investigation the oil was found to decrease inflammation in skin tissue, once again an action thought to be due to modulating immune function. Specifically, the oil was found to markedly act with actions to block excessive cell growth, known as anti proliferative activity, while also it greatly inhibited markers of inflammation. These markers included various cytokines and also gamma interferon. In fact, through the powers of this oil nearly all elements associated with toxic inflammation are greatly reduced, including various collagen-associated molecules, cancer-inducing growth factors, and enzymes—the ones that can do us harm. “Strongly inhibited” were among the comments made by investigators. As well, it was found to decisively block those specialized genes directly associated with inflammation. This caused them to conclude that oregano oil is a “promising candidate for use” against inflammation and cancerous changes in skin tissues.
Also, to reiterate, according to Iranian investigators oregano compounds were found to reduce all the serious immune modulators. This was through a direct action on the genes. This led to a reduction in the excessive activity of T cells. The various inflammatory cytokines were significantly reduced, including the highly noxious tumor necrosis factor alpha. This led the researchers to stated that oregano oil would be useful to combat diseases associated with overactivity of immunity.
Wild oregano is far from specific to the skin. It helps reduce inflammation all throughout the body, including within all internal organs. Nothing is an exception to its powers. Consider an investigation in artificially induced colitis in animals. Treatment of the colitis condition with oregano oil decreased levels of all pro-inflammatory cytokines, including tumor necrosis factor alpha. A moderate dosage of oregano oil, only 1 per 1000, was sufficient to reduce all the key interleukin-based inflammation-promoters. The result was decreased mortality rate, combined with a better weight gain and reduced visible damage to colonic tissue. By influencing the genes, that is the production of the messenger form of RNA, it was concluded, oregano reverses the colitis pathology, a most significant finding.
In every conceivable animal model oregano proves itself invaluable. For instance, as shown by Chinese investigators oregano-treated pigs had fewer Escherichia coli in the jejunum, ileum, and colon than the control. This was thought to be the result of the greater inactivation of inflammation, once again by curbing inflammatory reactions through a genetic influence. Essentially, the oregano shuts off the potentially dangerous gene, greatly reducing, even eliminating, toxic markers in the intestines. Microscopic analysis proves that the intestinal membranes of oregano-treated pigs were far different than those in controls, far healthier, even healthier than normal. The fact is with the oregano therapy all the inflammatory cytokines, the ones capable of causing severe illness, where fully depressed.
Black seed oil
also offers this action. In a study in the Saudi Pharmaceutical Journal it was found to greatly alleviate airway restrictions and inflammation of the airways in bronchial asthma, once again through cytokine modulation. In yet another investigation it acted dramatically against the toxicity of artificially-induced airway damage, largely by halting the immune system-provoked cytokine storm. This was to such a degree that black seed was held as a “useful” herbal medicine against inflammation- and allergy-related lung conditions, including shortness of breath and asthma. Fennel and cumin were also found to have this action, both of which are found in specialized black seed oil capsules. Clearly, the spices have a most potent action against inflammatory changes in lung tissues.
Thus, when cytokine storm is described and discussed, there is no need for fear. It is just an excessive reaction by a typically compromised immune system. To halt this, even prevent it, wild oregano is the answer. This should be consumed as the wild, whole food, Mediterranean-source oil, the crude herb, ideally with Rhus coriaria, and the juice-essence or hydrosol. All are readily available and make the ideal supplements for daily use and prevention and also for intake to support a healthy, balanced immune response. There is no harm taking such whole food supplements with other formulas or even drugs. Wild oregano is the number one, most versatile natural medicine for human health. Take it to your major benefit, and your delight and joy. After all, in Greek “ora-ganos” means “delight of the mountains.” Black seed oil is also a natural powerhouse mentioned by the ancients. Use it ideally in combination with wild oregano oil for a double action for protecting the lungs, heart, skin, digestive tract, and more.
Gholijani, G., et al. 2015. Modulation of Cytokine Production and Transcription Factors Activities in Human Jurkat T Cells by Thymol and Carvacrol. Advanced Pharm. Bulletin. 5(Suppl. 1):653-660.
Gholijani, N., et al. Antiinflammatory, tissue remodeling, immunomodulatory, and anticancer activities of oregano essential oil in a human skin disease model. Biochim Open, 3:4.73-77.
Ingram, C. 2018. The Black Seed Oil Miracle. Lake Forest, IL: Knowledge House Publishers
Wang, H., Song, L., et al. 2017. The acute airway inflammation induced by PM2.5 exposure and the treatment of essential oils in Balboas/c mice. Published online, Mar. 9.
Zou, Y. 2016. Morphology and expression of tight junction proteins associated with modulation of selected intestinal bacteria and immune status in pig model. Biomed Res Int. Epub May 29.